Notably, we also noticed that most of the RACK1 interacted proteins, such as EIF5A (Ding et al. 2011), CSTB (Zhang, Shi, et al. 2016) and TAGLN (Zhou et al. 2016), are involved with tumor malignancy through PI3 K/pAKT pathways. This evidence concerns the gene EIF5A and neoplasm.