BCL2 and carcinoma: In several other studies, it has also been reported that altering Bcl-2 family proteins and activating the intrinsic pathway are induced for apoptosis in human mesenchymal stem cells (Yadav et al. 2010) and cytotoxic effect through the activation of the intrinsic caspase-dependent apoptotic pathway is displayed in the human epithelial carcinoma cell line treated with arsenite (Arshad et al. 2015).