In the brain of SCA7 patients, SUMO-1 and SUMO-2 are co-localized with ataxin-7 aggregates and SUMOylation decreases the aggregation propensity as well as the toxicity of polyQ-expanded ataxin-7 (Janer et al. 2010). This evidence concerns the gene ATXN7 and spinocerebellar ataxia 7.