Further, in a study done on the vitreous humour of diabetic retinopathy, it has been found that the pro-renin, relative to albumin and other plasma proteins, was higher in vitreous fluid from eyes with proliferative diabetic retinopathy complicated by traction retinal detachment than in eyes of nondiabetic subjects with spontaneous retinal detachment. This evidence concerns the gene REN and diabetic retinopathy.