TIMP3 and myocardial infarction: This is in line with the data from the pig study, in which TIMP3 inhibition of cardiac remodeling was demonstrated by reducing LVEDV and LV wall thinning in the pig MI model.31 A highly glycosylated Fc fused TIMP3 (v82‐Fc) exhibited longer half‐life (15 hours) in the rat after IV delivery, which is suitable for bi‐weekly injection scheme.