POLE and thyroid gland undifferentiated (anaplastic) carcinoma: In the fatal forms of non-anaplastic thyroid cancer, besides mutations in TERT promoter, TP53, POLE, PI3K/AKT/mTOR pathway effectors, high frequency mutations of SWI/SNF subunits, histone methyltransferases, MED12 and RBM10 were identified [35].