In addition, in non-malignant cells, both Rab5A and its effector EEA1 (Supplementary Figure 1) were concentrated in the perinuclear region, whereas in prostate cancer cells, these endosomal compartments were found throughout the cytoplasm, with some compartments located toward the cell periphery in cellular extensions (Figure 4). This evidence concerns the gene EEA1 and Familial prostate cancer.