NOX2 co-located with Appl1, Rab5A, EEA1 and Rab7 endosome markers in non-malignant cells, but the co-location of NOX2 with these different endosome compartments was significantly increased in prostate cancer cells (Figure 4 and Supplementary Figure 1). The gene discussed is EEA1; the disease is prostate carcinoma.