In literature several dominantly inherited loci have been associated with PAP including PAP1 located on 7p14.1 with the associated gene GLI3 (MIM 174200), PAP2 located on chromosome 13q21–q32 (MIM 263450), and PAPA3 also having features of PAP-A/B with chromosomal address 19p13.1–13.2 (MIM 607324). Here, GLI3 is linked to pulmonary alveolar proteinosis.