Adipocyte-specific deficiency of CD1d in obese mice attenuates the responses of iNKT cells to αGalCer, leading to reduced expression of IL-4 and IL-2 in iNKT cells, subsequent impairment of the anti-inflammatory responses mediated by M2 macrophages and Treg cells, and aggravation of adipose tissue inflammation and insulin resistance (99–101). The gene discussed is IL4; the disease is Insulin resistance.