CD8A and Insulin resistance: In support of this, depletion of CD8+ T cells in obese mice dramatically decreases numbers of M1 macrophages and CLSs in adipose tissue, accompanied by an improvement of insulin sensitivity, whereas adoptive transfer of CD8+ T cells into CD8-deficient mice fed with HFD increases numbers of adipose tissue macrophages and CLSs, with elevated levels of proinflammatory cytokines and aggravated insulin resistance (30).