CD1D and Insulin resistance: Depletion of iNKT cells (deficient in Jα18) or deficiency of CD1d in mice exacerbates HFD-induced weight gain, adipocyte hypertrophy, fatty liver, and insulin resistance as compared with wild type controls, whereas adoptive transfer of iNKT cells into obese Jα18-deficient mice or activating iNKT cells by lipid ligand α-galactocylceramidee (αGalCer) in obese wild-type mice reverses HFD-induced phenotypes, with reduced weight gain and adipocyte hypertrophy, and alleviated fatty liver and insulin resistance.