IL17A and obesity due to melanocortin 4 receptor deficiency: Nevertheless, Bertola and colleagues found that IL-17–producing T cells are dramatically increased in SAT from overweight or obese individuals compared with that from lean subjects and further demonstrated that DCs from obese subjects may drive the differentiation of Th17 cells, which produce high amounts of IL-17, indicating that Th17 cells may directly participate in adipose tissue inflammation and insulin resistance in obesity (80).