Although the roles of neutrophil proteases, and in particular NE and CG in antibacterial defense, as well as NE and PR-3 in the cleavage of connective tissue components facilitating neutrophil access to the site of infection are relatively well-established, their extended specificities have never been determined in detail and no systematic bioinformatic screenings for potential substrates have been performed. This evidence concerns the gene PRTN3 and infection.