KEGG annotation showed that oncogenic pathways (pathways in cancer, chronic myeloid leukemia, and the TNF signaling pathway), immune-associated pathways (T cell and B cell receptor signaling pathways, inflammatory mediator regulation of TRP channels, TGF-beta signaling pathway, cytokine-cytokine receptor interaction, and NF-kappa B signaling pathway), and important proliferative, survival, and apoptosis signaling pathways (MAPK, AMPK, ErbB, Ras, Wnt, mTOR, and p53) were significantly enriched (Figure 4C). This evidence concerns the gene TP53 and chronic myelogenous leukemia, BCR-ABL1 positive.