TP53 and cancer: KEGG annotation showed that oncogenic pathways (pathways in cancer, chronic myeloid leukemia, and the TNF signaling pathway), immune-associated pathways (T cell and B cell receptor signaling pathways, inflammatory mediator regulation of TRP channels, TGF-beta signaling pathway, cytokine-cytokine receptor interaction, and NF-kappa B signaling pathway), and important proliferative, survival, and apoptosis signaling pathways (MAPK, AMPK, ErbB, Ras, Wnt, mTOR, and p53) were significantly enriched (Figure 4C).