On the other hand, hypoxia inhibited mRNAs coding for cytokines and/or receptors mainly involved in anti-tumor and anti-viral immune responses including IFNγ, IFI30, IFI44, IL-17RC, IL1RL1, and various components of the tumor necrosis factor (TNF) superfamily, such as TNFα, LTA, LTB, TNFSF10,11,14, and TNFRSF18 (55–63). The gene discussed is IL1RL1; the disease is neoplasm.