The early downregulation of genes coding for IFNγ and for several members of the TNF family, such as TNFα, LTA, LTB, TNFSF14, TNFSF10, and TNFSF11, is of particular interest given the role of these molecules in triggering tumor immunogenicity, decreasing tumor proliferation and angiogenesis, and favoring apoptotic tumor cell killing. This evidence concerns the gene TNFSF11 and neoplasm.