SPP2 and neoplasm: Compared to their normoxic counterparts, Hy-NK cells showed increased expression of genes coding for molecules with a primary role in angiogenesis (VEGFA, VEGFB, ADM, SPP1, FGF11) and promotion of inflammation or lymphocye cytotoxic responses (SPP1, SPP2, VEGF, TNFRSF11A and 12A, IGFBP2, FGFBP2, PTAFR), but also in apoptosis inhibition (IGF1R, TNFRSF10D, 11A, and 12A), tumor progression (IGFBP2, SPP1, MIF, PDGFD, TGFβ2, FGF11), and immunosuppression (MIF and TGFβ2) (34, 37, 48, 50–55).