The early downregulation of genes coding for IFNγ and for several members of the TNF family, such as TNFα, LTA, LTB, TNFSF14, TNFSF10, and TNFSF11, is of particular interest given the role of these molecules in triggering tumor immunogenicity, decreasing tumor proliferation and angiogenesis, and favoring apoptotic tumor cell killing. The gene discussed is TNF; the disease is neoplasm.