TNFSF18 and graft versus host disease: Member of the TNF-receptor superfamily, binds TNFSF18; modulates T-lymphocyte survival in peripheral tissues, important for interactions between activated T-lymphocytes and ECs; participates in the development of autoimmune/inflammatory responses and graft-vs- host disease and potentiates response to infection and tumors through activation of effector T-cells, inhibition of regulatory T (Treg) cells, NK-cell co-activation, activation of macrophages, modulation of DC function