PTH and hyperlipidemia: Experiments in mice have indicated that hyperlipidemia more prominently blunted the anabolic action of PTH in the cortical bone than in the trabecular bone (51, 52); however, Kuipers et al. (16) observed a cross-sectional association between HDL-C level and trabecular BMD but not between HDL-C level and cortical BMD or integral BMD at the hip or whole body measured by dual-energy X-ray absorptiometry (16).