The increased BBB permeability reported by both Warrington et al. (2014) and Clayton et al. (2018), is partly supported by clinical studies which demonstrated that in women developing preeclampsia, blood levels of S100B, neuronal specific enolase (NSE) and neurofilament light chain (NfL), three markers of cerebral injury, were higher than those observed in women with normal pregnancies (Bergman et al., 2018). The gene discussed is ENO2; the disease is preeclampsia.