As recent reports imply that central apelin-13 may contribute to BP regulation and play a causative role in neurogenic hypertension, we hypothesized that APJ signaling in the RVLM may contribute to the development of hypertension through regulation of SNA and that targeting this central APJ pathway may be an important new strategy in modulating sympathetic outflow to reverse or prevent hypertensive pathology. This evidence concerns the gene APLN and Hypertension.