A long-term BP regulatory function for APJ may become apparent only in other pathophysiological conditions and it remains to be established whether APJ may play a critical role in other models of hypertension such as deoxycorticosterone acetate-salt, that activates both the vasopressinergic and sympathetic nervous systems, or angiotensin II-induced hypertensive rats. Here, APLNR is linked to hypertensive disorder.