TNFSF10 and neoplasm: This finding is supported by studies that have demonstrated the use of SMAC mimetics in combination with TNF-α, TRAIL, IFN-γ, or certain methods of producing inflammatory cytokines to exploit synergistic effects on tumor cell death (Fulda and Vucic, 2012; Beug et al., 2014; Tanzer et al., 2017).