In conclusion, although HCC cell line HepG2 and HCCLM3 were resistant to APG-1387 monotherapy, APG-1387 could sensitize them to TNF-α- or TRAIL-induced apoptosis, CSC inhibition, and also potentiated the cytotoxic effects of NK cells on these HCC cell lines in vitro and in vivo. This evidence concerns the gene TNF and hepatocellular carcinoma.