In the present study, APG-1387 enhanced the cytotoxic effects of TNF-α and TRAIL on HepG2 and HCCLM3 cells to some extent, but the combination of APG-1387 with TNF-α or TRAIL resulted in a strong inhibitory effect on clonogenic survival, demonstrating long-term anti-tumor activity. This evidence concerns the gene TNFSF10 and neoplasm.