It was previously demonstrated that autophagy, a self-degradative process relying on lysosome, contributed to the alleviative effect mediated by activating CB2 in several inflammatory related diseases including multiple sclerosis, alcoholic liver disease and inflammatory bowel disease (Shao et al., 2014; Denaes et al., 2016; Ke et al., 2016). Here, CNR2 is linked to alcoholic liver diseases.