It was previously demonstrated that autophagy, a self-degradative process relying on lysosome, contributed to the alleviative effect mediated by activating CB2 in several inflammatory related diseases including multiple sclerosis, alcoholic liver disease and inflammatory bowel disease (Shao et al., 2014; Denaes et al., 2016; Ke et al., 2016). This evidence concerns the gene CNR2 and multiple sclerosis.