Thus, we evaluated the expression of EGFR and ErbB2, the expression and phosphorylation of MAPKs, including ERK1/2, the p38 kinase and the c-Jun N-terminal kinases (JNKs p54 and p46) by Western blotting after treatment of MM cells with AT-101 at 12.5 μM for 48 h. The gene discussed is ERBB2; the disease is Miyoshi myopathy.