In addition, gossypol prevents the interaction between Bcl-2 and Beclin-1 at the endoplasmic reticulum, decreases the levels of Bcl-2 and increases Beclin-1 expression by inducing Beclin-1 Atg5-a dependent autophagic pathway in cancer cells (Lian et al., 2011). This evidence concerns the gene BCL2 and cancer.