CD274 and cancer: For example, a potential upregulation of PD-L1 in vivo induced by resveratrol would render tumors more sensitive to immune check point inhibitors targeting PD-L1, however this phenomenon may also raise the concern that in individuals without cancer, the prolonged administration of resveratrol could favor cancer development since a putative upregulation of PD-L1 by resveratrol in transformed cells could promote immune evasion and tumor development.