Early studies indeed reported that, by inducing the expression of death proteins on the surface of tumor cells, including the death receptor 4 and death receptor 5 (DR4 and DR5 respectively), resveratrol was able to improve the tumor cells elimination by immune cells, especially natural killer cells (NK cells) expressing the corresponding TNF-related apoptosis-inducing ligand (TRAIL) (Hu et al., 2012; Pan et al., 2017). This evidence concerns the gene TNFRSF10B and neoplasm.