It could reduce lipid accumulation in adipocytes (Han et al., 2016), inhibit adipocyte differentiation (Han et al., 2016), improve insulin sensitivity, glycemic control, and lipid metabolism in diet-induced obese (DIO) mice (Fu et al., 2015), and ameliorate diabetic complications such as diabetic retinopathy (Qi et al., 2011; Xin et al., 2012) and diabetic-related erectile dysfunction (Liu et al., 2011; Wang et al., 2017). The gene discussed is INS; the disease is diabetes mellitus.