When the conditioned medium of MCs isolated from an AD-induced BALB/c mouse was added to RBL2H3 cells, it increased the expression levels of hallmarks of allergic inflammation, induced interactions of FcεRIß with HDAC3, SOCS1, and Lyn (Figure 14B), and increased ß-hexosaminidase activity (Figure 14C). Here, HDAC3 is linked to Alzheimer disease.