Atopic dermatitis increased the expression levels of hallmarks of allergic inflammation, induced interactions of FcεRIβ with histone deacetylase 3 (HDAC3) and Lyn, increased ß-hexosaminidase activity, increased serum IgE level, and increased the amount of histamine released in an MIP-2-dependent manner. This evidence concerns the gene HDAC3 and atopic eczema.