IL1B and type 2 diabetes mellitus: This pilot study led to subsequent, large trials of anti-IL-1β monoclonal antibodies gevokizumab, LY2189102, and – particularly – canakinumab in T2D, which all confirmed clinical benefits (Cavelti-Weder et al., 2012; Rissanen et al., 2012; Sloan-Lancaster et al., 2013).