Lessons from autoinflammatory diseases extend and apply beyond this group of rare conditions: deregulated activation of the myeloid compartment and IL-1 also mediate several common diseases, which can also be classified as autoinflammatory disorders (i.e., gout, pericarditis), or at least include autoinflammation as part of disease pathogenesis (i.e., heart failure, diabetes, myocarditis; Cavalli et al., 2016a; Hayashi et al., 2016; Netea et al., 2017). Here, IL1A is linked to myocarditis.