IL1B and arthritic joint disease: Autoinflammatory diseases are a spectrum of hereditary or multifactorial conditions variably manifested with clinical and hematologic features of IL-1-mediated inflammation: these include fever, fatigue, myalgia, arthralgia, arthritis, serositis, gastrointestinal involvement, skin rashes, and multi-organ involvement, often accompanied by neutrophilia and elevated inflammatory markers.