IL-1 blockade is highly effective in these conditions (Cavalli and Dinarello, 2015), as exemplified by several published cases of myocarditis associated with SoJIA and AOSD and promptly controlled by anakinra (Raffeiner et al., 2011; Movva et al., 2013; Choi et al., 2014; Cavalli et al., 2015b). This evidence concerns the gene IL1B and adult-onset Still disease.