The central role of IL-1-mediated inflammation is established in the pathogenesis of atherosclerosis, ischemia-reperfusion injury, cardiac remodeling, and myocardial infarction (Pomerantz et al., 2001; Kamari et al., 2007; Duewell et al., 2010; Ridker et al., 2017). The gene discussed is IL1B; the disease is atherosclerosis.