In agreement, mice lacking Egr-1 exhibit defects in durable long term potentiation (LTP) and memory (Jones et al., 2001), and Egr-1 is over-expressed in brains of AD patients and AD mouse models (Bakalash et al., 2011; Hendrickx et al., 2013; Gatta et al., 2014). Here, EGR1 is linked to Alzheimer disease.