ITGAM and Alzheimer disease: The purpose of this study was (1) to investigate the effect of repeated systemic administration of LPS on amyloid pathology in the APPSWE/PS1ΔE9 transgenic (Tg) mouse model of AD, and anticipating that effects of LPS on Aβ pathology would be microglial-dependent, to (2) define the microglial disease associated proteome by proteomic profiling of CD11b+ central nervous system (CNS) myeloid cells from 24-month-old Tg and wild type (Wt) mice and tissue from the LPS- and vehicle-injected Tg and Wt mice.