CLU and Alzheimer disease: In addition, we found two proteins, APOE and Clu, both being risk factors of sporadic AD (Scheltens et al., 2016), to be increased in Tg mice and CNS myeloid cells from Tg mice as well as being expressed in primary microglia and co-localize to or be co-expressed in CD11b+ microglia in Tg mice.