ITGAM and Alzheimer disease: In line with findings by others in mouse models of AD (Simard et al., 2006; Frank et al., 2008; Hickman et al., 2008) and observations in the postmortem cortex from AD cases (Vehmas et al., 2003; Liu et al., 2005; Bradshaw et al., 2013), we found that the CD11b+ microglia in LPS- and PBS-injected 12-month-old Tg mice clustered around the Aβ plaques and appeared to sequester Aβ in vacuole-like structures, in their processes.