Recently it was shown that conditional knockout mice lacking type 1 inositol 1,4,5-trisphosphate receptor (IP3R1) specifically in the cerebellum and brainstem, experienced dystonia the symptoms of which were independent of the basal ganglia, and could be rescued by inactivation of the cerebellum, inferior olive or in the absence of Purkinje cells (Hisatsune et al., 2013). Here, ITPR1 is linked to Dystonia.