It has been previously shown that PX can induce caspase-3 activation at 1000 μM and apoptotic cell death in other cell types like neuroblastoma cells (Carlson et al., 2000) and that inhibition of caspases protected against PX-induced cell death in pulmonary epithelium (Angelini et al., 2015). Here, CASP3 is linked to neuroblastoma.