SNCA and Parkinson disease: The membrane binding ability of α-synuclein and localization to MAM is abolished in α-synuclein carrying the familial PD mutation A30P (Jensen et al., 1998; Guardia-Laguarta et al., 2014) and this is associated with decreased MAM activity and mitochondrial-ER interface (Guardia-Laguarta et al., 2014).