Recent investigations of this early phase allowed us to demonstrate by use of the ratiometric calcium sensor, Fura-2 that it is characterized by a reduction in cytosolic Ca2+ in both mitotic OLN-93 and a non-mitotic human neuroblastoma cell model (SH-SY5Y) of α-synuclein aggregate stress, and in primary cultures of mouse hippocampal neurons expressing human α-synuclein from the Thy1-a-Syn Line 61 (Betzer et al., 2018). The gene discussed is SNCA; the disease is neuroblastoma.