All these findings in favor of the “GC theory” reinforce the hypothesis that long-term exposure to stress or stress-related disorders (like MDD or Cushing’s syndrome for instance), contributes to cognitive impairment, Aβ accumulation, Tau hyperphosphorylation, excitotoxicity, and neuroinflammation processes, leading to later development of AD. This evidence concerns the gene MAPT and Cushing syndrome due to macronodular adrenal hyperplasia.