APP and Alzheimer disease: In different Tg animal models of AD, chronic stress improved plaque pathology, accelerated the inception of cognitive deficits, triggered APP misprocessing, reduced Aβ clearance, increased Aβ levels, stimulated Tau hyperphosphorylation and its neuronal accumulation (Dong et al., 2004; Green et al., 2006; Jeong et al., 2006; Huang et al., 2011; Rothman et al., 2012).