EGFR and metastatic neoplasm: As stated earlier, 20% of patients with colorectal cancers are diagnosed with metastatic disease and 40% develop metastatic disease in their lifetime, and that 50% of patients are RAS wildtype and thus candidate for EGFR antibodies, thus the use of panitumumab for this population will lower the cost of care by more than 150 million dollars per year for payers.