Although TEAD4 amplification was identified in selected cancers [33, 38], genetic amplification of TEAD4 was not prominent as evidenced by the fact that less than 2.5% HNSCC samples harbored genetic alternations of TEAD4, thus largely precluding the possibility of genetic amplification of TEAD4 responsible for its overexpression in most HNSCC samples. The gene discussed is TEAD4; the disease is head and neck squamous cell carcinoma.