Consequently, TEAD4 protein abundance can be classified into low (55) or high expression (50) in HNSCC samples while negative (7), low (9) or high expression (4) in normal oral epithelial samples, indicative of aberrant TEAD4 overexpression in HNSCC (P < 0.0001, Chi square test). This evidence concerns the gene TEAD4 and head and neck squamous cell carcinoma.