The ultrasound and MRI can differentiate between them as the selective affection of the medial head of gastrocnemius and soleus more than the lateral head in calpain-3 deficiency (LGMD2A), selective involvement of the soleus in x-linked EDMD [17], and affection of the periphery of the gastrocnemius and soleus muscle, showing a rim in between them and the special affection of the middle of the rectus femoris muscle, and the central shadow sign in Bethlem myopathy [18]. Here, CAPN3 is linked to Emery-Dreifuss muscular dystrophy.