In fact, it has been suggested that miR-200c and miR-205 downregulation in tumor cells is an essential early step in the development of metastasis because of its important role as promotor of cancer progression20 at least in part through the regulation of E-cadherin expression during the epithelial-mesenchymal transition targeting its transcriptional repressors ZEB1 and ZEB220. This evidence concerns the gene CDH1 and cancer.