Moreover, our IHC revealed a significant positive correlation between ANXA1 and p-AKT expression (r = 0.619, P < 0.001) (Supplementary Table S3), and p-AKT and SQSTM1 expression in 127 NPCs (r = 0.594, P < 0.001) (Supplementary Table S4), indicating that ANXA1 inhibits autophagy by AKT signaling activation in the clinical NPC samples. Here, ANXA1 is linked to nasopharyngeal carcinoma.