SQSTM1 and nasopharyngeal carcinoma: As ANXA1 expression was significantly higher in high metastatic 5–8F NPC cells than that in non-metastatic 6–10B NPC cells (Fig. 1c), we downregulated ANXA1 expression in the 5–8F cells and upregulated its expression in the 6–10B cells, using the lentiviral vector-expressing ANXA1 shRNA or ANXA1, and observed that ANXA1 positively regulated SQSTM1 expression in the NPC cells (Fig. 1c).