ATG5 and nasopharyngeal carcinoma: To determine whether ANXA1-suppresed autophagy promotes NPC cell migration, invasion and metastasis, we used siRNA against BECN1 or ATG5 to inhibit autophagy in the ANXA1 KD NPC cells and scramble shRNA control cells, and observed that both siRNAs significantly increased the migration and invasion of ANXA1 KD NPC cells, but had not obvious effect on the migration and invasion of scramble shRNA control cells (Fig. 5a, b).