BECN1 and nasopharyngeal carcinoma: The results showed that knockdown of either BECN1 or ATG5 significantly increased the in vivo metastasis of ANXA1 KD NPC cells, but had not obvious effect on the metastasis of scramble shRNA control cells (Fig. 5d), indicating that ANXA1-suppresed autophagy enhances in vivo NPC cell migration.