The results showed that the genetic and chemical inhibition of autophagy downregulated E-cadherin while upregulated N-cadherin and Vimentin in the ANXA1 KD NPC cells, but only had slight effect on the EMT markers expression in the scramble shRNA control NPC cells (Fig. 6c), indicating that ANXA1-suppresed autophagy induces EMT-like alterations in the NPC cells. The gene discussed is CDH2; the disease is nasopharyngeal carcinoma.