To explore whether SQSTM1 is involved in the effect of ANXA1-suppresed autuphagy on Snail levels, we knocked down and overexpressed SQSTM1 in the NPC cells respectively, and observed that SQSTM1 OE increased the protein level of Snail in the ANXA1 KD NPC cells, whereas SQSTM1 KD decreased the protein level of Snail in the ANXA1 OE NPC cells, indicating that ANXA1-suppresed autophagy inhibits the degradation of Snai1 protein in a SQSTM1-dependent manner. Here, SNAI1 is linked to nasopharyngeal carcinoma.