To investigate the molecular mechanism of USP15 in the regulation of proliferation and apoptosis in MM cells, the expression of Caspase-3, PARP1, Bcl-2, Bcl-xL, Survivin, nuclear NF-κBp65, and cytoplasmic NF-κBp65 was measured by real-time PCR and/or western blot. This evidence concerns the gene USP15 and Miyoshi myopathy.