Moreover, the expression of Bcl-2, Bcl-xL, Survivin, nuclear NF-κBp65, and cytoplasmic NF-κBp65 was significantly decreased, and the expression of cleaved Caspase-3 and PARP1 was increased in MM cells after PDTC treatment (Fig. 7). This evidence concerns the gene BIRC5 and Miyoshi myopathy.