USP15 and Miyoshi myopathy: Given the role of NF-κBp65 in transcriptional regulation, we evaluated the possible effect of NF-κBp65 on the regulation of USP15 mRNA by transfecting MM cells with a luciferase reporter vector containing the 3′UTR region of USP15 with or without PDTC (50 μM) or LPS (1 μg/ml) treatment.