In the present study, to investigate whether NFAT1 is capable to promote melanoma growth and metastasis by influencing TAM properties, A375 and WM451 cells were cultured with conditioned medium from TAMs that had been transfected with pcDNA3.1-NFAT1, si-NFAT1 for 48 h. This evidence concerns the gene NFATC2 and melanoma.