WT1 and Wilms tumor: Importantly, mutations in WT1 lead to Wilms' tumor disease, the most common pediatric kidney cancer (Aiden et al., 2010; Rivera and Haber, 2005; Schedl and Hastie, 1998), which is characterized by diffuse Wilms' tumor precursor lesions exhibiting large active chromatin domains resembling those found in human ESCs (hESCs), together with a disturbed MET process (Aiden et al., 2010).