In this study, Freedman and colleagues showed that ADPKD iPSCs, as well as somatic epithelial cells and hepatoblasts/biliary precursors differentiated from these cells, expressed lower levels of polycistin-2 (PC2), encoded by the PKD2 gene (Freedman et al., 2013). This evidence concerns the gene PKD2 and autosomal dominant polycystic kidney disease.