DICER1 and glomerulosclerosis: Similarly, conditional deletion of Dicer1 in mature podocytes resulted in glomerular abnormalities, such as glomerulosclerosis and fibrosis (Harvey et al., 2008; Zhdanova et al., 2011), and podocyte-specific deletion of Drosha (Box 1) resulted in collapsing glomerulopathy comparable to the phenotype of Dicer1 knockouts (Zhdanova et al., 2011).