Conversely, HoxB7-Cre-mediated removal of Dicer1 caused the development of renal cysts in this model (Nagalakshmi et al., 2011) Independent studies have also shown the effects of Dicer1 deletion in Foxd1+ progenitor cells (Box 1), which give rise to renal stroma (Nakagawa et al., 2015; Phua et al., 2015). The gene discussed is DICER1; the disease is cystic kidney disease.