We compared the mutation spectrum of our aggregated HT115 branch variant SNV call set with mutation spectra derived from tumor-normal whole-genome sequencing of group A POLE colon tumors (samples with mutant POLE but not mutant POLD1) (Shinbrot et al. 2014) generated by the TCGA Research Network and found high similarity (Fig. 3A). The gene discussed is POLD1; the disease is neoplasm.