POLD1 and colonic neoplasm: We compared the mutation spectrum of our aggregated HT115 branch variant SNV call set with mutation spectra derived from tumor-normal whole-genome sequencing of group A POLE colon tumors (samples with mutant POLE but not mutant POLD1) (Shinbrot et al. 2014) generated by the TCGA Research Network and found high similarity (Fig. 3A).