Remodeling of the extracellular matrix (ECM) in tumor tissue might be further underpinned by the significant changes in other ECM‐related proteins such as ELN, LTBP1, LTBP2, LTBP3, EMILIN2, FN1, CDH16, and EMCN and collagens COL8A1, COL12A1, COL28A1, and COL26A1, and enzymes including ITIH2, MMP14, ADAMTS7, SERPINE1, ANPEP, PAPLN, ADAMTSL5, GGT5, and CPXM1 detected in tumor tissue (Fig 3D and Appendix Table S1). The gene discussed is PAPLN; the disease is neoplasm.