In addition, carbonic anhydrase 9 (CA9) and angiopoietin‐related protein 4 (ANGPTL4), proteins known to respond to tumor hypoxia (Sedlakova et al, 2014; Carbone et al, 2018), showed 13‐ and 3.6‐fold increases, respectively, in tumor tissue (Fig 3D and Appendix Table S1). This evidence concerns the gene ANGPTL4 and neoplasm.