ALPL and hepatocellular carcinoma: To definitively rule out liver toxicity because of IL-12-LNP treatment, we also compared the mRNA levels of common liver transaminases (Glutamic-Oxaloacetic Transaminase 1, GOT1; Alkaline Phosphatase, ALPL; Glutamic Pyruvic Transaminase, GPT) in normal liver tissue between NST-LNP and IL-12-LNP treated HCC-bearing mice (Fig. 1e).