A total of 14 CLL cases, including 6 TP53 deficient patients, were infused with (0.14–11) × 108 CAR-T cells after chemotherapy conditioning (six with bendamustine, three with fludarabine/cyclophosphamide, and five with pentostatin/cyclophosphamide). This evidence concerns the gene TP53 and B-cell chronic lymphocytic leukemia.