TP53 and B-cell chronic lymphocytic leukemia: Fraietta et al. [70] retrospectively analyzed 41 R/R CLL patients who received CAR-T cell therapy, and by comparing the different characteristics of effective group and invalid group, they found that efficacy of CAR-T cells was determined by intrinsic potency, memory-related gene expression, subpopulation, cytokines, and so on, while it was not associated with age, previous treatment, tumor burden, or TP53 states.