Recently, impressive advancements in the treatment of hematologic malignancies with the immune checkpoint inhibitors targeting programmed cell death-1 (PD-1) receptor and its ligand (PD-L1) lead to the approval of nivolumab and pembrolizumab by the Food and Drug Administration for the treatment of classical Hodgkin lymphoma in relapsed or refractory cases. Here, CD274 is linked to Hodgkins lymphoma.