CD274 and Epstein-Barr virus infection: In addition, many studies have reported that non-GCB DLBCL shows higher PD-L1 expression than GCB DLBCL [5, 8, 9], and that similar to Hodgkin lymphoma, Epstein–Barr virus (EBV) infection probably plays an important role in inducing PD-L1 expression in DLBCL [4, 10, 11].