In inflammatory GD - IgA nephropathy/HSP mesangial cell activation is an initial consequence of IgA deposition, but mesangial-podocyte crosstalk leads to indirect podocyte injury which has cytoskeletal and signaling consequences, ie. indirect podocyte injury also contributes to glomerular damage observed in IgAN [14]. The gene discussed is CD79A; the disease is hereditary spastic paraplegia.