We discovered that the combination of TC, HDL, CEA and CA19–9 parameters significantly enhanced the positive predictive rate for colon cancer diagnosis in patients, with the highest rate 87.5% (Table 3) in comparison with the combination of three or two of the four parameters respectively; although the combination of three parameters had significantly higher positive predictive rate than the combination of two parameters, and the latter also had higher predictive rate than individual parameter (Table 3). Here, CEACAM5 is linked to malignant colon neoplasm.