Some immunohistochemical marker of EMPD are also positive in specific type of breast cancer such as human epidermal growth factor receptor 2 (Her2/erbB2), carcinoembryonic antigen (CEA), cytokeratin 7 (CK7) and gross cystic disease fluid protein 15 (GCDFP15) [1, 23, 28–32]. The gene discussed is ERBB2; the disease is extramammary Paget disease.