When comparing the myocardial transcriptomes of wild type (wt) with cardioprotective IRF3−/− knockout mice in GSEA, PorSignDBs myocardial infarction tissue signatures were induced (Fig. 1f, UP), while non-infarcted healthy control heart tissue signatures were suppressed (Fig. 1f, DN). The gene discussed is IRF3; the disease is myocardial infarction.