Here, we show that non-cell-autonomous invasion promoted by centrosome amplification is mediated by a secretory response that culminates with the secretion of multiple pro-invasive factors, including IL-8, ANGPTL4, PAI, MSN, and GDF-15, previously implicated in cancer invasion (Chang et al., 2012, Duffy, 2004, Tan et al., 2012, Wang et al., 2017, Waugh and Wilson, 2008). Here, CXCL8 is linked to cancer.