Here, we show that non-cell-autonomous invasion promoted by centrosome amplification is mediated by a secretory response that culminates with the secretion of multiple pro-invasive factors, including IL-8, ANGPTL4, PAI, MSN, and GDF-15, previously implicated in cancer invasion (Chang et al., 2012, Duffy, 2004, Tan et al., 2012, Wang et al., 2017, Waugh and Wilson, 2008). This evidence concerns the gene SERPINE1 and cancer.