Importantly, induction of centrosome amplification in the breast cancer cells lines MCF-7 (p53 WT) and HCC-1954 (p53 mutant), which are of luminal and basal origin, respectively, was also sufficient to induce paracrine invasion in the recipient MCF10A cells (Figure 7G and Table S1). The gene discussed is TP53; the disease is hepatocellular carcinoma.