Moreover, LBP is an acute-phase protein [8, 9] that binds to lipopolysaccharide to induce the downstream TLR-4 signaling pathways of innate immunity and the inflammatory pathway of NASH, liver fibrosis and metabolic related diseases [10, 11, 15, 16]. The gene discussed is TLR4; the disease is metabolic dysfunction-associated steatohepatitis.