INS and obesity due to melanocortin 4 receptor deficiency: At the baseline, the subjects with obesity had significantly higher body weight, BMI, WC, soft lean mass, visceral fat mass, waist to hip ratio, fasting glucose, insulin, HOMA-IR, triglycerides, uric acid, WBC, hs-CRP, ALT, γ-GT, C-peptide, and NFS than those in the normal BMI group (Table 1).