A multi-center study revealed that NLR is positively correlated with hepatic steatosis activity score, pro-inflammatory cytokines and CRP [40], though in our multi-variate analysis the associations between hepatic steatosis and all types of leucocytes were attenuated, indicating that hepatic steatosis might play a lesser role in mediating systemic leucocytes circulation. The gene discussed is CRP; the disease is fatty liver disease.