In multivariable analyses, CX3CL1 (OR 1.4, 95% CI 1.06–1.84, p = 0.016) and the extent of baseline fibrosis (OR 1.5, 95% CI 1.26–1.74), p<0.001) were associated with new onset of significant lung fibrosis (AUC = 0.87). Here, CX3CL1 is linked to fibrosis.