For cancer cells that express PD‐L1 to affect macrophage activity, Gordon and the team found that PD‐1 expression on TAMs correlates with phagocytosis inhibition and total in vivo phagocytosis levels.24 The other study has demonstrated that CD163+ M2‐like macrophage infiltration is highly associated with PD‐L1 expression in gastric adenocarcinomal cells.25 This evidence concerns the gene PDCD1 and cancer.