The previous study showing that human PBMC treated with 1 mM baicalin can significantly enhance the IFN‐γ secretion in the cell culture supernatants.31 Additionally, PBMC from ulcerative colitis patients intervened by baicalin were obviously elevated the levels of IL‐10.32 In our study, we also found an increased level of IL‐10 expression in RAW 264.7 and in bone marrow derived M2 macrophages (data not shown). The gene discussed is IL10; the disease is ulcerative colitis.